Semple CAM, Taylor MS.
Science 2009.

From Semple and Taylor, Science Vol. 323, no. 5912, 16 January 2009. Reprinted with permission from AAAS.

From Semple and Taylor, Science Vol. 323, no. 5912, 16 January 2009. Reprinted with permission from AAAS.

An invited article for the perspectives section of Science Magazine. We highlight recent findings that show how the packaging of DNA in the germline nucleus can influence the rate and spectrum of genetic changes. We also consider this in the broader context of emerging evidence for the structure and function of features in a genome influencing mutation rate at a fine scale.

doi:10.1126/science.1169408 [PMID:19150834]